Benzyl Bromide → 4-Benzyl-2-chloro-pyrimidine

HRID 429760Notes

Reaction equation

HRID 429760 reaction equation
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[CH:12][N:11]=1>>[Cl:9][C:10]1[N:15]=[C:14]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:13]=[CH:12][N:11]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 775312,4-Dichloropyrimidine

Product 1

HCID 183533314-Benzyl-2-chloro-pyrimidine

Procedure

The title compound (quantitiative yield) was prepared from benzyl bromide (1.71 g, 1.19 ml, 10 mmol) and 2,4-dichloropyrimidine (1.49 g, 10 mmol) in a similar manner to Intermediate 2, and was used without purification.

Workup

  1. customwas used without purification

Sources & evidence

ORD record
ord-fbe8224fb98940a19e885c83a9c33465
Source dataset
uspto-grants-2001_11
Patent number
US06319922B1

Reaction notes

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