Benzyl Bromide → HCID 70076711, compound

HRID 429763Notes

Reaction equation

HRID 429763 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](O)=[CH:4][CH:3]=1.[CH2:9](Br)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[C:17](=[O:20])([O-])[O-].[Cs+].[Cs+]>>[CH2:9]([C:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=1[O:20][C:17]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=1[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 3

HCID 7498Benzyl BromideHCID 78084-BromophenolHCID 10796Cesium carbonate

Product 1

HCID 70076711HCID 70076711, compoundYield 84.7%

Procedure

The title compound (6.22 g, 82%) was prepared from 4-bromophenol (5.0 g, 28.9 mmol), benzyl bromide (3.44 ml, 28.9 mmol) and cesium carbonate (10.36 g, 31.8 mmol) in a similar manner to Intermediate 76. 1H NMR (CDCl3) δ 7.50-7.30 (7H, m), 6.86 (2H, d, J 8.8 Hz) and 5.05 (2H, s).

Sources & evidence

ORD record
ord-06368825befb4afd880fe80d2b43096f
Source dataset
uspto-grants-2001_11
Patent number
US06319922B1

Reaction notes

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