Glutaric anhydride → HCID 22335517, compound

HRID 429855Notes

Reaction equation

HRID 429855 reaction equation
[N:1]1([CH:6]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH:7]([CH3:9])[CH3:8])[CH:5]=[CH:4][N:3]=[CH:2]1.[O:17]1[C:22](=[O:23])[CH2:21][CH2:20][CH2:19][C:18]1=[O:24]>C1COCC1>[N:1]1([CH:6]([C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:22](=[O:23])[CH2:21][CH2:20][CH2:19][C:18]([OH:24])=[O:17])=[CH:14][CH:15]=2)[CH:7]([CH3:9])[CH3:8])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 7940Glutaric anhydrideHCID 22335511HCID 22335511, compound

Product 1

HCID 22335517HCID 22335517, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 4-[1-(1H-imidazol-1-yl)-2-methylpropyl]benzenamine (0.023 mol) and dihydro-2H-pyran-2,6(3H)-dione (0.03 mol) in THF (200 ml) was stirred and refluxed for 12 hours. When the reaction was complete, the solvent was evaporated, yielding 7.5 g (±)-5-[[4-[1-(1H-imidazol-1-yl)-2-methylpropyl]phenyl]amino]-5-oxopentanoic acid (compound 218).

Workup

  1. temperaturerefluxed for 12 hours
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-a839f557b6c24601abc30b08f75d4e7a
Source dataset
uspto-grants-2001_11
Patent number
US06319939B1

Reaction notes

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