Benzyl chloroformate → HCID 18351240, compound

HRID 430629Notes

Reaction equation

HRID 430629 reaction equation
[NH2:1][C:2]1[S:10][C:5]2[CH2:6][NH:7][CH2:8][CH2:9][C:4]=2[C:3]=1[C:11](=[O:24])[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:14][CH:13]=1.[CH2:25]([O:32][C:33](Cl)=[O:34])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C(N(CC)CC)C>[NH2:1][C:2]1[S:10][C:5]2[CH2:6][N:7]([C:33]([O:32][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[O:34])[CH2:8][CH2:9][C:4]=2[C:3]=1[C:11](=[O:24])[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 10387Benzyl chloroformateHCID 18351238HCID 18351238, compound

Product 1

HCID 18351240HCID 18351240, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-Amino-3-(4-phenylbenzoyl)-4,5,6,7-tetrahydrothieno(2,3-c)pyridine was reacted with benzyloxycarbonyl chloride and triethylamine to afford the title compound as a solid (mp 83-85° C.). 1H NMR (CDCl3) 2.05 (m, 2H); 3.45 (m, 2H); 4.46 (s, 2H); 5.15 (s, 2H); 6.72 (bs, 2H) 7.35-7.66 (m, 14H)

Sources & evidence

ORD record
ord-e6b82c55577d40a48c57d0b9eb0a1fa7
Source dataset
uspto-grants-2001_11
Patent number
US06323214B1

Reaction notes

Loading…