反应详情

A solution of 5-bromoisophthalic acid dimethylester (542 mg, 2 mmol) and 4-vinylpyridine (206 mg, 2 mmol), Pd(OAc)2 (8 mg), tri-o-tolylphosphine (30 mg) in 5 ml Et3N (5 ml) was stirred at 80° C. for overnight. The reaction mixture was purified by silica gel column eluted by 50% EtOAc in hexane to afford the product (65% yield). MS+=297. 1H NMR (CDCl3, 400 MHz) 8.64 (s, 1H), 8.61 (d, 2H), 8.38 (d, 2H), 7.40 (m, 2H), 7.35 (m, 1H), 7.21 (m, 1H), 4.02 (s, 6H);

1. customThe reaction mixture was purified by silica gel column
2. washeluted by 50% EtOAc in hexane