Hydrochloric Acid → HCID 59048191, compound

HRID 431371Notes

Reaction equation

HRID 431371 reaction equation
[Li+].[OH-].C[O:4][C:5](=[O:24])[C:6]1[CH:15]=[C:14]([CH:16]=[CH:17][C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[CH:13]=[C:8]([C:9]([O:11]C)=[O:10])[CH:7]=1.Cl>O.CCO>[N:21]1[CH:20]=[CH:19][C:18]([CH:17]=[CH:16][C:14]2[CH:13]=[C:8]([C:9]([OH:11])=[O:10])[CH:7]=[C:6]([CH:15]=2)[C:5]([OH:24])=[O:4])=[CH:23][CH:22]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 69913671HCID 69913671, compound

Product 1

HCID 59048191HCID 59048191, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of LiOH (2.5 mmol) in water (1 ml) was added to 5-(2-pyridin-4-yl-vinyl)-isophthalic acid dimethylester (297 mg, 1 mmol) suspended in 5 ml EtOH. The mixture was stirred at room temperature. The reaction was monitored by TLC until completion. 2.5 ml 1 M HCl solution was then added and the mixture was evaporated to dryness. The product was used in next step without further purification.

Workup

  1. customthe mixture was evaporated to dryness
  2. customThe product was used in next step without further purification

Sources & evidence

ORD record
ord-1dea7b29f09343ac85a917ee49cdee22
Source dataset
uspto-grants-2003_12
Patent number
US06656971B2

Reaction notes

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