反应详情

Into a solution of 3.00 g of 4-nitrophenol and 3.31 mL of triethylamine in 30 mL of tetrahydrofuran, 2.46 mL of isopropyl chloroformate was dropped under cooling on ice. To the reaction mixture, after stirred at the same temperature for 10 min, ethyl acetate and water were added. The organic layer was separated, washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, followed by solvent removal by evaporation under reduced pressure. The residue was dissolved in 50 mL of ethyl acetate, washed with a 5% potassium carbonate aqueous solution and a saturated sodium chloride aqueous solution successively and dried over anhydrous magnesium sulfate. After removing the solvent by evaporation under reduced pressure, 3.00 g of 4-nitrophenyl isopropyl carbonate was obtained as a light yellow solid.

1. temperatureunder cooling on ice
2. customThe organic layer was separated
3. washwashed with a saturated sodium chloride aqueous solution
4. dry with materialdried over anhydrous magnesium sulfate
5. customfollowed by solvent removal by evaporation under reduced pressure
6. dissolutionThe residue was dissolved in 50 mL of ethyl acetate
7. washwashed with a 5% potassium carbonate aqueous solution
8. dry with materiala saturated sodium chloride aqueous solution successively and dried over anhydrous magnesium sulfate
9. customAfter removing the solvent
10. customby evaporation under reduced pressure