反应详情

Into a solution of 3.00 g of 4-nitrophenol and 3.31 mL of triethylamine in 30 mL of tetrahydrofuran, 2.75 mL of butyl chloroformate was dropped under cooling on ice. To the reaction mixture, after stirred at the same temperature for 10 min, ethyl acetate and water were added. The organic layer was separated, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate. After removing the solvent by evaporation under reduced pressure, 4.60 g of butyl 4-nitrophenyl carbonate was obtained as a light yellow oily matter.

1. temperatureunder cooling on ice
2. customThe organic layer was separated
3. washwashed with a saturated sodium chloride aqueous solution
4. dry with materialdried over anhydrous magnesium sulfate
5. customAfter removing the solvent
6. customby evaporation under reduced pressure