Hydrochloric Acid → HCID 22171686, compound

HRID 432869Notes

Reaction equation

HRID 432869 reaction equation
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][C:12]([CH3:15])=[CH:11][CH2:10]1)=O)(C)(C)C.FC(F)(F)C(O)=O.[ClH:23]>C1(OC)C=CC=CC=1.ClCCl.O1CCOCC1>[ClH:23].[NH2:8][CH:9]1[CH2:14][CH2:13][C:12]([CH3:15])=[CH:11][CH2:10]1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 22171687HCID 22171687, compound

Product 1

HCID 22171686HCID 22171686, compound

Reagents, catalysts & solvents 3

HCID 6344DichloromethaneSolventHCID 7519AnisoleSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 1-tert-butoxycarbonylamino-4-methylcyclohex-3-ene (0.4 g) in a mixture of anisole (0.4 ml) and dichloromethane (0.8 ml) was added trifluoroacetic acid (1.2 ml) at 0° C. and the mixture was allowed to stir at 0° C. for 1 hour. Evaporation gave a residue, which was taken up into a solution of hydrogen chloride in dioxane (4N, 2 ml). Evaporation under reduced pressure and trituration with diisopropyl ether gave 1-amino-4-methylcyclohex-3-ene hydrochloride, which was used without further purification.

Workup

  1. customEvaporation
  2. customgave a residue, which
  3. customEvaporation under reduced pressure and trituration with diisopropyl ether

Sources & evidence

ORD record
ord-13b88b32df044419a48d9aaf2e16e853
Source dataset
uspto-grants-2003_12
Patent number
US06664293B2

Reaction notes

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