反应详情

温度

70 °C

To a solution of 1 g (4.3 mmole) (4S,5S)-5-(4-tert-butylphenyl)-4-methyl-oxazolidin-2-one p in 10 mL N,N-dimethylformamide was added 5.2 mL (5.2 mmole) 1 M potassium tert-butoxide in tetrahydrofuran. To the resulting gel was added 0.4 mL (4.7 mmole) iodoethane. The reaction mixture was heated at 70° C. for 1 hr. Cold water (25 mL) was added and the mixture was extracted with 30 mL ethyl acetate. The organic phase was washed with two 10 mL portions water, dried (magnesium sulfate) and concentrated under reduced pressure. (4S,5S)-5-(4-tert-Butylphenyl)-4-methyl-3-ethyl-oxazolidin-2-one Q was isolated as a crystalline solid from ethyl acetate/hexane, 1.06 g. M+H=261.

1. extractionthe mixture was extracted with 30 mL ethyl acetate
2. washThe organic phase was washed with two 10 mL portions water
3. dry with materialdried (magnesium sulfate)
4. concentrationconcentrated under reduced pressure