反应详情

3.02 g of N-[2-fluoro-5-(2-hydroxyphenoxy)-4-nitrophenyl]acetamide was dissolved in 20 ml of N,N-dimethylformamide, then, 1.5 g of potassium carbonate was added, and the mixture was stirred for 1 hour at room temperature. Then, 1.6 g of methyl bromoacetate was added at room temperature. The mixture was stirred for 2 hours under the same condition, poured into water, extracted with ethyl acetate, and the organic layer was washed with dilute hydrochloric acid, washed with water, dried over magnesium sulfate and concentrated, and the resulted crystal was washed with t-butyl methyl ether to obtain 3.01 g of methyl [2-(5-acetylamino-4-fluoro-2-nitrophenoxy)phenoxy]acetate.

1. stirringThe mixture was stirred for 2 hours under the same condition
2. extractionextracted with ethyl acetate
3. washthe organic layer was washed with dilute hydrochloric acid
4. washwashed with water
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated
7. washthe resulted crystal was washed with t-butyl methyl ether