Chlorosuccinimide → HCID 72739620, compound

HRID 434044Notes

Reaction equation

HRID 434044 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[CH:4]=[N:5][OH:6].[Cl:12]N1C(=O)CCC1=O>CN(C)C=O>[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](=[N:5][OH:6])[Cl:12]

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 533950272,4-Difluoro-benzaldehyde oxime

Product 1

HCID 72739620HCID 72739620, compoundYield 68.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a fashion similar to that for preparation 14, 2,4-difluorobenzaldehyde oxime (2.52 g, 16.1 mmol), N-chlorosuccinimide (2.21 g, 16.5 mmol), and dimethyl formamide (25 ml) gave 2,4-difluorobenzoyl chloride oxime (2.11 g, 68%) after chromatography (silica gel, hexanes/ether).

Sources & evidence

ORD record
ord-e791cf51eb754382b6a98a2ef6fd6803
Source dataset
uspto-grants-2003_12
Patent number
US06670373B1

Reaction notes

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