Tetrahydrofuran → HCID 88732154, compound

HRID 434310Notes

Reaction equation

HRID 434310 reaction equation
OCC[CH:4]([Cl:8])[C:5]([NH2:7])=[O:6].C(O[CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH:21]=[CH2:22])C.C(=O)([O-])[O-:24].[K+].[K+].[O:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1>CS(O)(=O)=O>[Cl:8][CH2:4][C:5]([NH:7][CH:30]([O:29][CH:33]([O:24][CH:21]([O:20][CH2:19][CH2:18][O:17][CH2:16][CH2:15][O:14][CH2:13][CH3:12])[CH3:22])[CH3:32])[CH3:31])=[O:6]

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 11430Potassium CarbonateHCID 13187412HCID 13187412, compoundHCID 54531899HCID 54531899, compound

Product 1

HCID 88732154HCID 88732154, compound

Reagents, catalysts & solvents 1

HCID 6395Methanesulfonic AcidCatalyst

Procedure

Two grams (g) (0.0145 mole) of hydroxyethyl chloroacetamide and 3.3 g (0.0146 mole) of ethoxyethoxyethoxyethoxy ethene were combined and dissolved in 5 milliliters (ml) of tetrahydrofuran. The reaction mixture was cooled in an ice bath and 2 drops of methane sulfonic acid were added. The mixture was allowed to stir for approximately 2 hours and then 25 ml of a 5% aqueous solution of potassium carbonate were added. The product was extracted with dichloromethane, dried and stripped.

Workup

  1. temperatureThe reaction mixture was cooled in an ice bath
  2. extractionThe product was extracted with dichloromethane
  3. customdried

Sources & evidence

ORD record
ord-d085382c9b92449db0c74347c68ea4cc
Source dataset
uspto-grants-1983_08
Patent number
US04396419

Reaction notes

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