Benzaldehyde → 37622-81-4

HRID 435468Notes

Reaction equation

HRID 435468 reaction equation
[ClH:1].[NH2:2][C@@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH2:5][S:6][CH3:7].NC(C(O)=O)CCSC.C(=O)C1C=CC=CC=1.Cl>C(O)(=O)CC>[ClH:1].[NH2:2][CH:3]([C:8]([OH:10])=[O:9])[CH2:4][CH2:5][S:6][CH3:7]

Participants

6

Reactant 4

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 876(+-)-MethionineHCID 9942337D-Methionine, hydrochloride

Product 1

HCID 1021972537622-81-4Yield 103.3%

Reagents, catalysts & solvents 1

HCID 1032Propionic AcidSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3 g of D-methionine hydrochloride, 50 ml of propionic acid, 0.48 g of DL-methionine (0.2 mole per mole of D-methionine hydrochloride) and 0.16 ml of benzaldehyde (0.1 mole per mole of D-methionine hydrochloride) was stirred at 100° C. for 2 hours. After the reaction, 0.34 g of 35% hydrochloric acid was added to the mixture, and said mixture was ice-cooled. The crystalline precipitates were collected by filtration, and then washed with acetone. 3.10 g of DL-methionine hydrochloride were thereby obtained.

Workup

  1. additionwas added to the mixture
  2. temperaturecooled
  3. customThe crystalline precipitates
  4. filtrationwere collected by filtration
  5. washwashed with acetone

Sources & evidence

ORD record
ord-3cb96afc4b0b46a596e5e727d99f4cc7
Source dataset
uspto-grants-1983_08
Patent number
US04401820

Reaction notes

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