反应详情

4.2 g (0.021 moles) of carnitine hydrochloride are dissolved in 12 mls of trifluoroacetic acid, then at 35° C. and under vigorous stirring 20 cc of a solution of anhydrous chloroform wherein about 4.36 g (0.021 moles) of the acide chloride of the N-acetyl glutamic acid have been dissolved are added dropwise. The reaction is allowed to proceed for about 14 hours at 35° C., and subsequently at 50° C. for two further hours. The reaction mixture is cooled. Upon acetone addition (40 mls) no precipitate forms even though the mixture is cooled below 0° C. 140 mls of ethyl ether are added and after keeping the mixture at 8° C. overnight there are obtained 6.2 g of a solid white product which is crystallized with ethyl ether. After 2 crystallizations 5.4 g (68%) of the desired product having the following characteristics are obtained:

1. dissolutionhave been dissolved
2. additionare added dropwise
3. customsubsequently at 50° C.
4. temperatureThe reaction mixture is cooled
5. temperatureis cooled below 0° C
6. customat 8° C.
7. customovernight