反应详情

11.4 g of 10,11-dihydro-2-trifluoromethyl-dibenzo[b,f]thiepin-10-ol, 100 ml of benzene and 4 g of calcium chloride are saturated with hydrochloric acid gas for 2 hours at 15° C and subsequently stirred at room temperature for 3 hours. The mixture is filtered and concentrated under reduced pressure. There is obtained 10-chloro-10,11-dihydro-2-trifluoromethyl-dibenzo[b,f]thiepin in the form of yellow crystals.

1. filtrationThe mixture is filtered
2. concentrationconcentrated under reduced pressure