Hydrochloric Acid → HCID 21430436, compound

HRID 437154Notes

Reaction equation

HRID 437154 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)(=[O:13])=[O:12].[CH3:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.Cl>O>[CH3:20][N:21]1[CH2:26][CH2:25][N:24]([C:2]2[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=2[S:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)(=[O:13])=[O:12])[CH2:23][CH2:22]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 7679004-Chloro-3-(morpholine-4-sulfonyl)-benzoic acid

Product 1

HCID 21430436HCID 21430436, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

273 Grams of 4-chloro-3-morpholinosulfonylbenzoic acid (1.0 mole) were heated under reflux for 5 hours with 0.5 l of N-methylpiperazine. Subsequently the excess base was completely eliminated in vacuo, the residue was dissolved in 2 l of water, and the pH value of the solution was adjusted to 8 by means of 5N HCl. After standing for 3 days at room temperature, the crystalline precipitate was suction-filtered and was recrystallized from water.

Workup

  1. filtrationthe crystalline precipitate was suction-filtered
  2. customwas recrystallized from water

Sources & evidence

ORD record
ord-2b29b13824ff4be3bd89f4cf767d1e98
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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