Hydrochloric Acid → HCID 21430479, compound

HRID 437167Notes

Reaction equation

HRID 437167 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11](=[O:18])(=[O:17])[N:12]([CH2:15][CH3:16])[CH2:13][CH3:14].[CH3:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1.Cl>O>[CH2:13]([N:12]([CH2:15][CH3:16])[S:11]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:2]=1[N:23]1[CH2:24][CH2:25][N:20]([CH3:19])[CH2:21][CH2:22]1)[C:6]([OH:8])=[O:7])(=[O:18])=[O:17])[CH3:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 76789859210-68-3

Product 1

HCID 21430479HCID 21430479, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

29 Grams of 4-chloro-3-diethylsulfamoyl-benzoic acid were heated with 30 g of N-methylpiperazine for 4 hours at 140° C. Subsequently the reaction solution, which had cooled down to 80° C., was introduced into 0.4 l of water, and the solution was neutralized with 5N HCl. As soon as the precipitate, which was amorphous at first, became crystallized, it was suction-filtered and recrystallized from methanol.

Workup

  1. custombecame crystallized
  2. filtrationit was suction-filtered
  3. customrecrystallized from methanol

Sources & evidence

ORD record
ord-77603e5be4f74524bc48c3710eec6500
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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