Hydrochloric Acid → HCID 21430443, compound

HRID 437168Notes

Reaction equation

HRID 437168 reaction equation
[CH2:1]([NH:4][S:5]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[Cl:17])[C:11]([OH:13])=[O:12])(=[O:7])=[O:6])[CH:2]=[CH2:3].[CH3:18][N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.Cl>CN(C)C=O>[ClH:17].[CH2:1]([NH:4][S:5]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[N:22]1[CH2:23][CH2:24][N:19]([CH3:18])[CH2:20][CH2:21]1)[C:11]([OH:13])=[O:12])(=[O:7])=[O:6])[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 255595659210-69-4

Product 1

HCID 21430443HCID 21430443, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 28 g of 3-allylsulfamoyl-4-chlorobenzoic acid, 30 g of N-methylpiperazine and 20 ml of dimethylformamide was heated for 4 hours at 140° C. When the reaction solution was subsequently introduced into 0.3 l of 2N HCl, the monohydrochloride crystallized immediately. The product was then purified by recrystallization from water.

Workup

  1. customthe monohydrochloride crystallized immediately
  2. customThe product was then purified by recrystallization from water

Sources & evidence

ORD record
ord-22db37c1153c4e6eb2315d84f5487608
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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