Hydrochloric Acid → HCID 21430502, compound

HRID 437173Notes

Reaction equation

HRID 437173 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11]([N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)(=[O:13])=[O:12].[CH3:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1.Cl>O>[ClH:1].[CH3:19][N:20]1[CH2:25][CH2:24][N:23]([C:2]2[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=2[S:11]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)(=[O:13])=[O:12])[CH2:22][CH2:21]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 10701984-Chloro-3-(pyrrolidine-1-sulfonyl)-benzoic acid

Product 1

HCID 21430502HCID 21430502, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

29.0 Grams of 4-chloro-3-pyrrolidinosulfonylbenzoic acid (0.1 mole) were heated with 50 ml of N-methylpiperazine for 4 hours under reflux. Subsequently the reaction solution was introduced into 0.3 l of water, and the pH value of the mixture was adjusted to 3.0 by means of 5N HCl. After having been allowed to stand over night at room temperature, the precipitate was suction-filtered, recrystallized from water and dried at 100° C.

Workup

  1. temperatureunder reflux
  2. waitto stand over night at room temperature
  3. filtrationthe precipitate was suction-filtered
  4. customrecrystallized from water
  5. customdried at 100° C.

Sources & evidence

ORD record
ord-7d047c9661d5430384a644258e7bc78d
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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