3,4-dihydro-2H-pyran → HCID 10998760, compound

HRID 441837Notes

Reaction equation

HRID 441837 reaction equation
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[CH:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][C:8]=1[OH:17].C(=O)([O-])[O-].[Na+].[Na+]>Cl>[O:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]1[O:17][C:8]1[CH:9]=[CH:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 80803,4-dihydro-2H-pyranHCID 86632-NaphtholHCID 10340Sodium Carbonate

Product 1

HCID 10998760HCID 10998760, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Procedure

To a solution of 2 drops of 6N hydrochloric acid in 17 g. of dihydropyran is added 14.4 g. of β-naphthol under ice cooling. The resulting solution is stirred at 5° to 10° for 2 hours and then 5 g. of anhydrous sodium carbonate is added. After stirring at room temperature for 15 minutes, the resulting solids are filtered off and the filtrate is concentrated under reduced pressure to yield crude 2-tetrahydropyranyloxynaphthalene, suitable for use in the next step (2).

Workup

  1. stirringAfter stirring at room temperature for 15 minutes
  2. filtrationthe resulting solids are filtered off
  3. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-a5a4b4f2f0dd4fa2a0e40eaefb8156f6
Source dataset
uspto-grants-1977_08
Patent number
US04042704

Reaction notes

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