反应详情

A mixture of 9-(2-morpholinylmethyl)-9,10-dihydro-9,10-methanoanthracene (50 mg), cyclopropylmethyl bromide (40 mg) and sodium amide (15 mg) in dry benzene was refluxed for 10 hours. The reaction mixture was diluted with benzene and water. The benzene layer was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness to give 9-(4-cyclopropylmethyl-2-morpholinylmethyl)-9,10-dihydro-9,10-methanoanthracene, M.P. 88° - 90° C.

1. temperaturewas refluxed for 10 hours
2. washThe benzene layer was washed with water
3. dry with materialdried over anhydrous sodium sulfate
4. customevaporated to dryness