反应详情

1,2-Epoxy-3-octadecyloxypropane (5.0 g, 15.3 mmol) is added to a mixture of piperazine (1.94 g, 22.5 mmol) and anhydrous potassium carbonate (100 mg) in dimethyl formamide (60 mL) over a 30 minute period under a nitrogen atmosphere. The resultant mixture is stirred at 80°-90° C. (oil bath temperature) for 48 hours. The reaction mixture is cooled to room temperature and concentrated in vacuo to leave a residue. The residue is stirred with chloroform (125 mL). The undissolved material is filtered in vacuo, and the filtrate is concentrated in vacuo, purified by chromatography and dried in vacuo to afford 1-[2'-hydroxy-3'-octadecyloxypropyl]-piperazine.

1. concentrationconcentrated in vacuo
2. customto leave a residue
3. filtrationThe undissolved material is filtered in vacuo
4. concentrationthe filtrate is concentrated in vacuo
5. custompurified by chromatography
6. customdried in vacuo