反应详情

温度

80 °C

To a solution of the compound from Example 3 (E1) (0.5 g, 1.6 mmol) and 1-iodo-3-trifluoroacetamidobenzene (0.5 g, 1.6 mmol) in triethylamine (10 mL) under an argon atmosphere was added a small amount of tetrakis(triphenylphosphine)palladium(0), copper(I) iodide and triphenylphosphine. The mixture was heated at 80° C. for 0.2 h, was cooled to room temperature and was concentrated in vacuo. The residue was purified by flash chromatography, eluting with 3:1 hexane/ethyl acetate, to give the title compound as a pale yellow solid (0.62 g, 78%), m.p. 63°-65° C.

1. temperaturewas cooled to room temperature
2. concentrationwas concentrated in vacuo
3. customThe residue was purified by flash chromatography
4. washeluting with 3:1 hexane/ethyl acetate