Hydrochloric Acid → HCID 67595937, compound

HRID 442864Notes

Reaction equation

HRID 442864 reaction equation
[ClH:1].[O:2]=[C:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][CH2:9][CH2:10][NH:11][C:12]([C:14]1[N:15]([CH2:36][CH2:37][N:38]([CH3:40])[CH3:39])[C:16]2[C:21]([C:22]=1[CH:23]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:13]>C(OCC)(=O)C.C(O)C>[ClH:1].[O:2]=[C:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][CH2:9][CH2:10][NH:11][C:12]([C:14]1[N:15]([CH2:36][CH2:37][N:38]([CH3:40])[CH3:39])[C:16]2[C:21]([C:22]=1[CH:23]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:13]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67595938HCID 67595938, compound

Product 1

HCID 67595937HCID 67595937, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

A solution of hydrogen chloride in 10 ml of ethyl acetate was added to a suspension of Compound 108 (12.85 g) obtained in Example 108 in 70 ml of ethanol, followed by stirring. Then, ethanol (45 ml) was added to the reaction solution followed by recrystallization to give 12.2 g (yield: 89%) of the title compound.

Workup

  1. customfollowed by recrystallization

Sources & evidence

ORD record
ord-ce2dff152be14cb49f020e29fd4ad2e0
Source dataset
uspto-grants-1999_04
Patent number
US05891902

Reaction notes

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