Phenacyl bromide → alpha-(4-Chloro-2-naphthoxy)acetophenone

HRID 443355Notes

Reaction equation

HRID 443355 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](O)=[CH:4][CH:3]=1.Br[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:16].C(=O)([O-])[O-:24].[K+].[K+]>C1C=CC=CC=1>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([O:24][CH2:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[CH:3]=1

Participants

5

Reactant 3

HCID 6259Phenacyl bromideHCID 11430Potassium CarbonateHCID 117874-Chloro-1-naphthol

Product 1

HCID 20563338alpha-(4-Chloro-2-naphthoxy)acetophenone

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The product of step A is reacted with α-bromoacetophenone in benzene in the presence of potassium carbonate using the method of Example 1, step A, to provide white crystals of α-(4-chloro-2-naphthoxy)acetophenone after recrystallization from a dichloromethane-petroleum ether mixture.

Sources & evidence

ORD record
ord-49ebc2f36ce748f498b98c8fa7f5d08c
Source dataset
uspto-grants-1981_04
Patent number
US04260547

Reaction notes

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