Water → HCID 12552502, compound

HRID 443848Notes

Reaction equation

HRID 443848 reaction equation
O=[C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7]C=2NC2=[CH:12][C:13]([C:15]([OH:17])=[O:16])=[N:14][N:3]12.[C:18](=O)([O-])[O-].[K+].[K+].CI.[OH2:26].[CH3:27][N:28]([CH3:31])[CH:29]=O>>[CH3:27][N:28]1[C:31]2[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=2[C:2](=[O:26])[N:3]2[N:14]=[C:13]([C:15]([O:17][CH3:18])=[O:16])[CH:12]=[C:29]12

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178524062HCID 178524062, compound

Product 1

HCID 12552502HCID 12552502, compoundYield 86%

Procedure

A mixture of 2.29 g of 4,9-dihydro-9-oxo-pyrazolo-[5,1-b]quinazoline-2-carboxylic acid, 5.52 g of anhydrous potassium carbonate and 34.2 g of methyl iodide in 100 ml of dimethyl formamide is stirred at room temperature for 3 days. Water is added and the white solid is filtered off to give 2.2 g (86%) of the ester; mp 287°-289° C. (d).

Workup

  1. filtrationthe white solid is filtered off

Sources & evidence

ORD record
ord-b0c74c0a3fbe4071b2c511c5e53ee02a
Source dataset
uspto-grants-1981_04
Patent number
US04261997

Reaction notes

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