Methane → HCID 54710798, compound

HRID 444219Notes

Reaction equation

HRID 444219 reaction equation
[CH2:1]([C:4]1[C:5]([O:23][CH2:24][CH:25]([OH:41])[CH2:26][N:27]2[CH2:32][CH2:31][N:30]([CH2:33][C:34]3[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=3)[CH2:29][CH2:28]2)=[CH:6][CH:7]=[C:8]2[C:13]=1[O:12][C:11](=[O:14])[CH:10]=[C:9]2[O:15]CC1C=CC=CC=1)[CH:2]=[CH2:3].C.[H][H]>CN(C=O)C>[Cl:40][C:37]1[CH:36]=[CH:35][C:34]([CH2:33][N:30]2[CH2:31][CH2:32][N:27]([CH2:26][CH:25]([OH:41])[CH2:24][O:23][C:5]3[C:4]([CH2:1][CH2:2][CH3:3])=[C:13]4[C:8]([C:9]([OH:15])=[CH:10][C:11](=[O:14])[O:12]4)=[CH:7][CH:6]=3)[CH2:28][CH2:29]2)=[CH:39][CH:38]=1

Participants

5

Reactant 3

HCID 297MethaneHCID 13408413HCID 13408413, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54710798HCID 54710798, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Hydrogenation of a solution of 1-[3-(8-allyl-4-benzyloxycoumarin-7-yloxy)-2-hydroxypropyl]-4-(4-chlorobenzyl)piperazine (7.2 g) in DMF (200 ml) over 10% palladinized charcoal at atmospheric pressure until two equivalents of hydrogen were absorbed gave 4.85 g (80%) of material of m.p. (aqueous ethanol) 107° C. (Found; C, 63.90; H, 6.59; N, 5.20; Cl, 6.53; C26H31N2O5Cl requires; C, 64.12; H, 6.42; N, 5.75; Cl, 7.28%).

Workup

  1. customwere absorbed

Sources & evidence

ORD record
ord-6789381ca1cf4042b0cd743ce81be61b
Source dataset
uspto-grants-1981_04
Patent number
US04263299

Reaction notes

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