Hydrochloric Acid → HCID 136335642, compound

HRID 444227Notes

Reaction equation

HRID 444227 reaction equation
[CH:1](=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[NH:10]([C:12]1[S:16][N:15]=[C:14]([C:17]([Cl:20])([Cl:19])[Cl:18])[N:13]=1)[NH2:11].Cl.C(O)C>O>[Cl:20][C:17]([Cl:18])([Cl:19])[C:14]1[N:13]=[C:12]([NH:10][N:11]=[CH:1][C:2]2[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=2)[OH:4])[S:16][N:15]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 6998SalicylaldehydeHCID 13014065HCID 13014065, compound

Product 1

HCID 136335642HCID 136335642, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.3 g (0.01 mole) salicylaldehyde, 2.4 g (0.01 mole) 5-hydrazino-3-trichloromethyl-1,2,4-thiadiazole, 1 ml hydrochloric acid (conc.), and 100 ml ethanol was heated 5 hours on a steam bath. Water was added and the solution cooled in a freezer several days. The resulting solid was removed by filtration to give 2.8 g (83% yield) (mp. 204°-205° C.).

Workup

  1. temperaturewas heated 5 hours on a steam bath
  2. temperaturethe solution cooled in a freezer several days
  3. customThe resulting solid was removed by filtration
  4. customto give 2.8 g (83% yield) (mp. 204°-205° C.)

Sources & evidence

ORD record
ord-8c98ce918e86413b9e60e33b90b7ba2b
Source dataset
uspto-grants-1981_04
Patent number
US04263312

Reaction notes

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