反应详情

温度

60 °C

Place 6-(5-methylthiophen-2-yl)-5-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-ol (105.7 mg, 0.23 mmol) in a vial. Add ethyl acetate (2 mL) and methanesulfonic acid (18 μL). Warm the resulting mixture to ˜60° C. with stirring. Add tetrahydrofuran (1 mL) to the resulting burnt orange solution with some dark brown gum on the bottom of the vial. Sonicate the resulting solution for 15 minutes. Carefully decant the suspension from gum that forms on the flask. Carefully collect the resulting solids by vacuum filtration and wash the resulting cake with pentane (2×2 mL). Dry the resulting solids in a 40° C. vacuum oven overnight to obtain the title compound. MP (DSC)=161.90° C.

1. customSonicate the resulting solution for 15 minutes
2. customCarefully decant the suspension from gum that
3. customCarefully collect the resulting solids
4. filtrationby vacuum filtration
5. washwash the resulting cake with pentane (2×2 mL)
6. customDry the resulting solids in a 40° C. vacuum oven overnight