Isoquinoline → HCID 86646593, compound

HRID 445240Notes

Reaction equation

HRID 445240 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[Cl:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]>C1COCC1>[Cl-:11].[C:1]1([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

4

Reactant 2

HCID 8405IsoquinolineHCID 10928Ethyl chloroformate

Product 1

HCID 86646593HCID 86646593, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Isoquinoline (5.50 g, 42.5 mmol) was dissolved into 50 mL of anhydrous THF and ethyl chloroformate (4.47 mL, 46.8 mmol) was added slowly. The resulting pale yellow mixture was stirred at RT for 30 min. Then, the resulting precipitate was collected via filtration through a cintered glass funnel and dried under vacuum for 2 days to yield the title compound as a pale yellow solid.

Workup

  1. additionwas added slowly
  2. filtrationThen, the resulting precipitate was collected via filtration through a cintered glass funnel
  3. customdried under vacuum for 2 days

Sources & evidence

ORD record
ord-5565e81e70ec4287a28415d7b2f35961
Source dataset
uspto-grants-2013_07
Patent number
US08476297B2

Reaction notes

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