反应详情

Lithium hydroxide monohydrate (0.67 g) was added to solution of ethyl 2-cyclopentylthiazole-4-carboxylate [Carboxylic Acid 2, step c] (0.9 g) in a mixture of THF (40 mL) and, water (10 mL). The resulting mixture was stirred overnight. The reaction was acidified with aqueous HCl (2M, 10 mL) and the solvent evaporated. The residue was partitioned between brine (50 mL) and ethyl acetate (50 mL) and the layers separated. The aqueous phase was extracted with ethyl acetate (2×50 mL). The combined organic solutions were dried over sodium sulphate, filtered and evaporated to give the titled compound as a pale yellow solid. Yield 0.77 g.

1. customthe solvent evaporated
2. customThe residue was partitioned between brine (50 mL) and ethyl acetate (50 mL)
3. customthe layers separated
4. extractionThe aqueous phase was extracted with ethyl acetate (2×50 mL)
5. dry with materialThe combined organic solutions were dried over sodium sulphate
6. filtrationfiltered
7. customevaporated