反应详情

4,5-Dimethyl-6-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyridazin-3-yl-acetonitrile (120 mg, 0.32 mmol) is combined with hydroxyl amine (63 mg, 0.96 mmol) and THF (2 mL). The reaction mixture is heated to reflux for 3 it Concentrate the reaction and redissolve the residue in dimethylacetamide dimethylacetal (500 μL). Heat this solution for 16 h at reflux. Concentrate the resulting mixture in vacuo. The residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2) to afford the title compound (62.3 mg, 45%).

1. temperatureThe reaction mixture is heated
2. temperatureto reflux for 3 it
3. concentrationConcentrate
4. customthe reaction
5. temperatureHeat this solution for 16 h
6. temperatureat reflux
7. concentrationConcentrate the resulting mixture in vacuo
8. customThe residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2)