反应详情

2-Chloro-6-bromobenzothiazole (2.29 g), piperazine (1.59 g) and sodium bicarbonate (3.10 g) were combined in isopropanol (75 mL) and the resulting orange solution was heated to reflux overnight, then concentrated to ˜15 mL, diluted with water, and extracted with DCM. The extracts were concentrated to yield an orange solid which was chromatographed (0 to 5% MeOH in DCM) to yield 6-bromo-2-(piperazin-1-yl)benzo[d]thiazole as a slightly pink solid. MS: 297.9 (M+H).

1. temperaturethe resulting orange solution was heated
2. temperatureto reflux overnight
3. concentrationconcentrated to ˜15 mL
4. additiondiluted with water
5. extractionextracted with DCM
6. concentrationThe extracts were concentrated
7. customto yield an orange solid which
8. customwas chromatographed (0 to 5% MeOH in DCM)