反应详情

温度

75 °C

To a mixture of 5-methylisatin (8.05 g, 50 mmol) and K2CO3 (8.16 g, 60 mmol) in DMF (100 mL) was added BnBr (6.5 mL, 55 mmol) dropwise over 2 min. After addition, the resulting mixture was heated in an oil bath at 75° C. for 1.5 h. After cooling to rt, the reaction mixture was poured onto ice/cold water (250 mL), rinsed with H2O (50 mL) and stirred for 5 min. The resulting precipitates were collected by suction filtration and air dried to give 1-benzyl-5-methylisatin as dark red solid. MS ESI 252.0 [M+H]+, calcd for [C16H13NO2+H]+ 252.1.

1. additionAfter addition
2. temperatureAfter cooling to rt
3. additionthe reaction mixture was poured onto ice/cold water (250 mL)
4. washrinsed with H2O (50 mL)
5. customThe resulting precipitates
6. filtrationwere collected by suction filtration and air
7. customdried