反应详情

温度

100 °C

7-(2-chloro-5-methoxy-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamine (0.33 mmol, 1.0 equiv), 4-bromo-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfonamide (0.5 mmol, 1.5 equiv), Cs2CO3 (0.99 mmol, 3.0 equiv), Pd2(dba)3 (0.033 mmol, 0.10 equiv.), and Xantphos (0.066 mmol, 0.2 equiv) were dissolved in 10 mL dioxane and refluxed at 100° C. under an argon atmosphere for 18 h. The reaction was cooled to room temperature and filtered. The filtrate was dissolved in EtOAc and washed with saturated NaHCO3 and brine, and the organic phase was dried (Na2SO4). The organics were concentrated under reduced pressure to afford residue that was purified by reverse phase HPLC using a 10-50-75 gradient over 30 minutes, and again concentrated under reduced pressure to afford 4-[7-(2-chloro-5-methoxy-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamino]-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfonamide, as a tan residue (168 mg, 90% yield). Rf=0.50 (9:1 DCM/MeOH) MS (ES+) m/z=567. LC retention time 2.82 min.

1. temperatureThe reaction was cooled to room temperature
2. filtrationfiltered
3. dissolutionThe filtrate was dissolved in EtOAc
4. washwashed with saturated NaHCO3 and brine
5. dry with materialthe organic phase was dried (Na2SO4)
6. concentrationThe organics were concentrated under reduced pressure
7. customto afford residue
8. customthat was purified by reverse phase HPLC
9. customover 30 minutes
10. concentrationagain concentrated under reduced pressure