Hydrochloric Acid → HCID 66994443, compound

HRID 449289Notes

Reaction equation

HRID 449289 reaction equation
CCOCC.[ClH:6].[CH3:7][N:8]([CH3:42])[CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:41])[C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:25]=[C:24]3[N:26]([CH2:29][C:30]4[CH:31]=[C:32]5[C:37](=[CH:38][CH:39]=4)[N:36]=[CH:35][CH:34]=[CH:33]5)[N:27]=[N:28][C:23]3=[CH:22][CH:21]=2)=[CH:16][C:15]=1[F:40]>C1COCC1>[ClH:6].[ClH:6].[CH3:42][N:8]([CH3:7])[CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:41])[C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:25]=[C:24]3[N:26]([CH2:29][C:30]4[CH:31]=[C:32]5[C:37](=[CH:38][CH:39]=4)[N:36]=[CH:35][CH:34]=[CH:33]5)[N:27]=[N:28][C:23]3=[CH:22][CH:21]=2)=[CH:16][C:15]=1[F:40]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 54671170HCID 54671170, compound

Product 1

HCID 66994443HCID 66994443, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ether saturated with HCl (1 ml) was added at 0° C. to a solution of example 72 (0.040 g. 0.082 mmol) in THF (1 ml), and stirred for 15 min. The precipitate formed was washed with ether and dried under vacuum to afford the title compound as an off-white solid (0.040 g, 88%). M.P.: 137-140° C. MS (m/z): 483.54 (M+−2HCl).

Workup

  1. customThe precipitate formed
  2. washwas washed with ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-99ebec555ed341ecbbac127d6a96dd28
Source dataset
uspto-grants-2013_07
Patent number
US08481739B2

Reaction notes

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