Hydrochloric Acid → HCID 66995286, compound

HRID 449308Notes

Reaction equation

HRID 449308 reaction equation
CCOCC.Cl.[Cl:7][C:8]1[CH:18]=[C:17]([C:19]2[N:24]=[C:23]3[N:25]([CH2:28][C:29]4[CH:30]=[C:31]5[C:36](=[CH:37][CH:38]=4)[N:35]=[CH:34][CH:33]=[CH:32]5)[N:26]=[N:27][C:22]3=[CH:21][CH:20]=2)[CH:16]=[CH:15][C:9]=1[C:10]([NH:12][CH2:13][CH3:14])=[O:11]>C1COCC1>[ClH:7].[Cl:7][C:8]1[CH:18]=[C:17]([C:19]2[N:24]=[C:23]3[N:25]([CH2:28][C:29]4[CH:30]=[C:31]5[C:36](=[CH:37][CH:38]=4)[N:35]=[CH:34][CH:33]=[CH:32]5)[N:26]=[N:27][C:22]3=[CH:21][CH:20]=2)[CH:16]=[CH:15][C:9]=1[C:10]([NH:12][CH2:13][CH3:14])=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 58514638HCID 58514638, compound

Product 1

HCID 66995286HCID 66995286, compoundYield 111.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ether saturated with HCl (1 ml) was added at 0° C. to a solution of example 119 (0.020 g. 0.045 mmol) in THF (1 ml), and stirred for 15 min. The precipitate formed was filtered, washed with ether and dried under vacuum to afford the title compound as an off-white solid (0.012 g, 56%). M.P.: 151-153° C.

Workup

  1. customThe precipitate formed
  2. filtrationwas filtered
  3. washwashed with ether
  4. customdried under vacuum

Sources & evidence

ORD record
ord-41bfec3762c04469849c92c49d9a7a74
Source dataset
uspto-grants-2013_07
Patent number
US08481739B2

Reaction notes

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