反应详情

温度

110 °C

5-((4-Methylpiperazin-1-yl)methyl)pyridin-2-amine (3.2 g, 15.5 mmol, Eq:1.00), 4-bromo-6-chloro-2-methylpyridazin-3(2H)-one (3.64 g, 16.3 mmol, Eq:1.05), xantphos (1.35 g, 2.33 mmol, Eq: 0.15) tris(dibenzylideneacetone)dipalladium (0) (1.07 g, 1.16 mmol, Eq: 0.075) and cesium carbonate (15.2 g, 46.5 mmol, Eq: 3.00) were added to a sealed tube under nitrogen. Dioxane (103 ml) was added and the solution was degassed with nitrogen. The tube was capped and heated at 110° C. overnight. The reaction mixture was filtered through celite and the cake was washed with DCM. 1M HCl was added to and the layers were separated. The aqueous layer was basified with 2M NaOH and extracted several times with DCM. Most of the solvent was evaporated and the residue was triturated with ether. The solid that formed was filtered and dried to give 2.75 g (50.8%) of product which was used without further purification.

1. customthe solution was degassed with nitrogen
2. customThe tube was capped
3. filtrationThe reaction mixture was filtered through celite
4. washthe cake was washed with DCM
5. addition1M HCl was added to and the layers
6. customwere separated
7. extractionextracted several times with DCM
8. customMost of the solvent was evaporated
9. customthe residue was triturated with ether
10. customThe solid that formed
11. filtrationwas filtered
12. customdried