反应详情

In a 4 mL vial was charged with quinolin-7-ol (0.200 g, 1.378 mmol) and sodium hydride (0.066 g, 1.653 mmol) in N,N-dimethylformamide (13.78 ml) to give a brown solution. The reaction was stirred at room temperature for 30 minutes and then 5-bromo-2,4-dichloropyrimidine (0.176 mL, 1.378 mmol) was added. The mixture was stirred at room temperature overnight. Diluted with 9:1 dichloromethane/methanol; washed with water and brine. The organic layer was dried over magnesium sulfate, filtered, and the solvent was removed under reduced pressure to afford a tan residue. (ESI(+)) m/e 337.7 (M+H)+.

1. customto give a brown solution
2. stirringThe mixture was stirred at room temperature overnight
3. washwashed with water and brine
4. dry with materialThe organic layer was dried over magnesium sulfate
5. filtrationfiltered
6. customthe solvent was removed under reduced pressure
7. customto afford a tan residue