Triethylamine → HCID 67024012, compound

HRID 450736Notes

Reaction equation

HRID 450736 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7](NC)[CH2:6][CH2:5]2.[CH2:13]([N:15](CC)CC)C.[C:20]([O:24]C(=O)CC)(=O)[CH2:21][CH3:22]>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([CH2:13][NH:15][C:20](=[O:24])[CH2:21][CH3:22])[CH2:6][CH2:5]2

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31263Propionic anhydrideHCID 61070798HCID 61070798, compound

Product 1

HCID 67024012HCID 67024012, compoundYield 97.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of (5-bromo-indan-1-yl)-methylamine (240 mg, 0.91 mmol) and triethylamine (363 mg, 3.60 mmol) in THF (5 mL) was stirred at 5° C. and propionic anhydride (125 mg, 0.96 mmol) added dropwise. After the mixture was stirred for 18 h at room temperature, the solvent was removed and ethyl acetate/water were added. The organic layer was washed with water and dried over MgSO4. The filtrate was concentrated to give a white solid (250 mg, 97%).

Workup

  1. customthe solvent was removed
  2. additionethyl acetate/water were added
  3. washThe organic layer was washed with water
  4. dry with materialdried over MgSO4
  5. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-41971cd639184a68a60c978ba8333297
Source dataset
uspto-grants-2013_07
Patent number
US08486984B2

Reaction notes

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