3,4-Difluoroaniline → HCID 178512264, compound

HRID 451527Notes

Reaction equation

HRID 451527 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[CH:10]1[CH:15]=[CH:14][C:13]([O:16][C:17](OC2C=CC=CC=2)=[N:18][C:19]#[N:20])=[CH:12][CH:11]=1>C(O)(C)C>[C:19](/[N:18]=[C:17](\[O:16][C:13]1[CH:14]=[CH:15][CH:10]=[CH:11][CH:12]=1)/[NH:5][C:4]1[CH:6]=[CH:7][C:8]([F:9])=[C:2]([F:1])[CH:3]=1)#[N:20]

Participants

4

Reactant 2

HCID 774693,4-DifluoroanilineHCID 688090Diphenyl N-Cyanocarbonimidate

Product 1

HCID 178512264HCID 178512264, compoundYield 86.4%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a solution of 3,4-difluoroaniline (646 mg, 5 mmol) in isopropanol (10 mL) was added diphenyl cyanocarbonimidate (1.19 g, 5 mmol) and the suspension was stirred at room temperature over night. The precipitate was filtered off, washed with isopropanol and dried under reduced pressure to yield the title compound as a white solid (1.18 g, 86%).

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with isopropanol
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-9229aa3c4d2446089f67ca26b6ef5c2b
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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