2-Methoxybenzaldehyde → HCID 178489319, compound

HRID 452059Notes

Reaction equation

HRID 452059 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.[CH3:11][O:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH:15]=O.[Si](C#N)(C)(C)C.[N:27]1([C:32](N2C=CN=C2)=[O:33])C=CN=[CH:28]1>>[NH:6]1[C:5]2[CH:9]=[CH:10][C:2]([N:1]3[CH:15]([C:14]4[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=4[O:12][CH3:11])[CH2:28][NH:27][C:32]3=[O:33])=[CH:3][C:4]=2[N:8]=[CH:7]1

Participants

5

Reactant 4

HCID 86582-MethoxybenzaldehydeHCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 82115Trimethylsilyl cyanide

Product 1

HCID 178489319HCID 178489319, compound

Procedure

The compound was synthesized starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 2-methoxybenzaldehyde (0.484 mL, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (1.05 mL, 7.55 mmol), di-(imidazol-1-yl)methanone (0.667, 4.12 mmol) as described in method 2.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-517ff090b9da43cc8a63a4a99c325f82
Source dataset
uspto-grants-2013_07
Patent number
US08486940B2

Reaction notes

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