Hydrochloric Acid → C-(1,4-Dioxa-spiro[4.5]dec-8-yl)-C-(4-methoxy-phenyl)-methylamine

HRID 45212Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([Mg]Br)=[CH:5][CH:4]=1.[O:11]1[C:15]2([CH2:20][CH2:19][CH:18]([C:21]#[N:22])[CH2:17][CH2:16]2)[O:14][CH2:13][CH2:12]1.S([O-])([O-])(=O)=O.[Na+].[Na+].[BH4-].[Na+].Cl.[OH-].[Na+]>C1COCC1.COC(C)(C)C.ClCCl>[O:11]1[C:15]2([CH2:20][CH2:19][CH:18]([CH:21]([NH2:22])[C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH2:17][CH2:16]2)[O:14][CH2:13][CH2:12]1

Participants

Conditions

Temperature: 0 °C

Procedure

Under argon, 4-methoxy-phenylmagnesium bromide (0.5M in THF, 24 mL, 12 mmol) was added to a solution of 1,4-dioxa-spiro[4.5]decane-8-carbonitrile (1.0 g, 6 mmol) in THF (100 mL). The mixture was stirred under reflux for 16 hours. The reaction mixture was then cooled to 0° C. Saturated sodium sulphate solution was added dropwise until no more precipitate formed. The precipitate was removed by filtration and washed with THF. The combined organic phases were stirred with sodium borohydride (452 mg, 12 mmol) overnight at 25° C. The reaction mixture was then diluted with t-butyl methyl ether (100 mL) and treated with 0.05M aqueous hydrochloric acid (three times with 100 mL). The combined aqueous phases were adjusted to alkaline pH with a 6M aqueous sodium hydroxide solution with cooling, before extraction with dichloromethane gave a solution of the desired product which was used directly in the next stage. Rt=0.74 min (Method 5). Detected mass: 278.2 (M+H+).

Workup

temperatureunder reflux for 16 hours
customformed
customThe precipitate was removed by filtration
washwashed with THF

Sources & evidence

ORD record: ord-057b2f14c04446eebc113d2a9dff6ddd
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08541449B2

Reaction notes

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