反应详情

Under classical Heck reaction conditions, 5-Bromo-1,3-dihydro-benzo[c]thiophene 2,2-dioxide was transformed with PPh3, Pd(OAc)2, TEA, and vinyltrimethylsilane at 90° C. in DMF. The crude product was extracted with CH2Cl2 and concentrated. Deprotection in CH2Cl2/TFA gave the pure product after purification with flash chromatography (CH2Cl2) in high yields.

1. extractionThe crude product was extracted with CH2Cl2
2. concentrationconcentrated
3. customDeprotection in CH2Cl2/TFA gave the pure product
4. customafter purification with flash chromatography (CH2Cl2) in high yields