Trifluoroacetic acid → HCID 58508464, compound

HRID 454552Notes

Reaction equation

HRID 454552 reaction equation
C1(SC)C=CC=CC=1.FC(F)(F)C(O)=O.C([O:23][C:24]1[CH:51]=[CH:50][C:49]([C:52]2[O:56][CH:55]=[N:54][CH:53]=2)=[CH:48][C:25]=1[C:26]([NH:28][C:29]1[CH:41]=[C:40]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[CH:39]=[CH:38][C:30]=1[C:31]([O:33]C(C)(C)C)=[O:32])=[O:27])C1C=CC=CC=1>>[OH:23][C:24]1[CH:51]=[CH:50][C:49]([C:52]2[O:56][CH:55]=[N:54][CH:53]=2)=[CH:48][C:25]=1[C:26]([NH:28][C:29]1[CH:41]=[C:40]([C:42]2[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=2)[CH:39]=[CH:38][C:30]=1[C:31]([OH:33])=[O:32])=[O:27]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7520ThioanisoleHCID 66990201HCID 66990201, compound

Product 1

HCID 58508464HCID 58508464, compoundYield 78%

Procedure

Thioanisole (2.3 mL) and trifluoroacetic acid (7.7 mL) were added to the obtained tert-butyl 2-(2-(benzyloxy)-5-(oxazol-5-yl)benzamido)-4-phenylbenzoate (0.21 g), followed by stirring at room temperature for 9 hours and 40 minutes. The solvent was evaporated under reduced pressure, and methanol was added to the residue. The solid substance was collected by filtration to obtain 0.12 g of 2-(2-hydroxy-5-(oxazol-5-yl)benzamido)-4-phenylbenzoic acid as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and methanol
  2. additionwas added to the residue
  3. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-ca87fab1579c4a119e827b410befcc78
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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