Potassium Carbonate → HCID 67109896, compound

HRID 455301Notes

Reaction equation

HRID 455301 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[C:4]([OH:17])[CH:3]=1.I[CH2:19][CH2:20][CH2:21][CH2:22][S:23]([NH:26][CH3:27])(=[O:25])=[O:24].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[C:4]([O:17][CH2:19][CH2:20][CH2:21][CH2:22][S:23](=[O:25])(=[O:24])[NH:26][CH3:27])[CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 67109671HCID 67109671, compoundHCID 86667510HCID 86667510, compound

Product 1

HCID 67109896HCID 67109896, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of tert-butyl 4-fluoro-2-hydroxybenzylcarbamate (Example 15; 12.2 mmol), 4-iodo-N-methylbutane-1-sulfonamide (Example 18; 18.3 mmol) and potassium carbonate (61 mmol) in DMF (60 ml) was stirred at 80° C. for 10 hours.

Sources & evidence

ORD record
ord-f61a1fcee0f144cb9800243ce325e5fc
Source dataset
uspto-grants-2013_07
Patent number
US08497270B2

Reaction notes

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