反应详情

To a mixture of (2,4,6-Trimethyltetrahydro-2H-pyran-4-yl)amine obtained in Example 9-4 (900 mg) and K2CO3 (1.2 g) in tetrahydrofuran (10 mL) cooled on an ice bath, were added (2S,4S)-1-(chloroacetyl)-4-fluoro-2-pyrrolidinecarbonitrile obtained in Example 7-11 (700 mg) and a catalytic amount of NaI. The reaction mixture was warmed to room temperature and stirred for 65 hrs.

1. temperaturecooled on an ice bath