反应详情

温度

45 °C

7.5 g (60 mmol) of 2-bromoethanol is added, under argon atmosphere, to a mixture of 10.35 g (50 mmol) of 1-(4-nitrophenyl)piperazine, 7.6 g (55 mmol) of K2CO3 and 9 ml (65 mmol) of Et3N in 200 ml of CH2Cl2. The whole is then heated at 45° C. for 18 hours. The reaction mixture is finally diluted with 50 ml water, agitated and decanted. The organic phase is washed with 50 ml of salt water, dried over MgSO4, filtered and concentrated under vacuum. The residue is crystallized from diisopropyl ether. A yellow solid is obtained with a yield of 89%. Melting point: 98–99° C.

1. customdecanted
2. washThe organic phase is washed with 50 ml of salt water
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated under vacuum
6. customThe residue is crystallized from diisopropyl ether
7. customA yellow solid is obtained with a yield of 89%