Water → HCID 23712812, compound

HRID 459458Notes

Reaction equation

HRID 459458 reaction equation
O.[OH-].[Li+:3].C[O:5][C:6]([C:8]1[O:9][C:10]2[CH2:11][N:12]([CH3:17])[CH2:13][CH2:14][C:15]=2[N:16]=1)=[O:7]>O1CCCC1>[CH3:17][N:12]1[CH2:13][CH2:14][C:15]2[N:16]=[C:8]([C:6]([O-:7])=[O:5])[O:9][C:10]=2[CH2:11]1.[Li+:3]

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 17842376HCID 17842376, compound

Product 1

HCID 23712812HCID 23712812, compoundYield 107.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Water (6.0 ml) and lithium hydroxide (99.7 mg) were added to a solution of 2-methoxycarbonyl-5-methyl-4,5,6,7-tetrahydrooxazolo[5,4-c]pyridine (800 mg) in tetrahydrofuran (24 ml) at room temperature, and the mixture was stirred for 10 minutes. The reaction mixture was concentrated under reduced pressure to obtain the title compound (825 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2fb317a880104a709680ef255a5ac435
Source dataset
uspto-grants-2007_03
Patent number
US07192968B2

Reaction notes

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